ParkinsonCanadaV1, Main, Exploration, bibRecord, 002644

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue

Identifieur interne : 002644 ( Main/Exploration ); précédent : 002643; suivant : 002645

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue

Auteurs : Jennifer E. Tobin [États-Unis] ; JING CUI [États-Unis] ; Jemma B. Wilk [États-Unis] ; Jeanne C. Latourelle [États-Unis] ; Jason M. Laramie [États-Unis] ; Ann C. Mckee [États-Unis] ; Mark Guttman [Canada] ; Samer Karamohamed [États-Unis] ; Anita L. Destefano [États-Unis] ; Richard H. Myers [États-Unis]

Source :

Brain research [ 0006-8993 ] ; 2007.

RBID : Pascal:07-0204910

Descripteurs français

Pascal (Inist)
- Sepiapterin reductase, Réaction chaîne polymérase, Bioptérine(tétrahydro), Parkinson maladie, Homme, Expression génique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Gene expression, Human, Parkinson disease, Polymerase chain reaction, Sepiapterin reductase, Tetrahydrobiopterin.

Abstract

The PARK3 locus on chromosome 2pl3 has shown linkage to both the development and age of onset of Parkinson's disease (PD). One candidate gene at this locus is sepiapterin reductase (SPR). Sepiapterin reductase catalyzes the final step in the biosynthetic pathway of tetrahydrobiopterin (BH₄), an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. The expression of SPR was assayed using semiquantitative real-time RT-PCR in human post-mortem cerebellar tissue from neuropathologically confirmed PD cases and neurologically normal controls. The expression of other enzymes involved in BH₄ biosynthesis, including aldose reductase (AKR1B1), carbonyl reductase (CBR1 and CBR3), GTP-cyclohydrolase I (GCH1), and 6-pyruvoyltetrahydrobiopterin (PTS), was also examined. Single-nucleotide polymorphisms around the SPR gene that have been previously reported to show association to PD affection and onset age were genotyped in these samples. Expression of SPR showed a significant 4-fold increase in PD cases relative to controls, while the expression of AKR1B1 and PTS was significantly decreased in PD cases. No difference in expression was detected for CBR1, CBR3, and GCH1. Genetic variants did not show a significant effect on SPR expression, however, this is likely due to the low frequency of rare genotypes in the sample. While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868471

Affiliations:

Le document en format XML

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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Brain research</title>
<title level="j" type="abbreviated">Brain res.</title>
<idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene expression</term>
<term>Human</term>
<term>Parkinson disease</term>
<term>Polymerase chain reaction</term>
<term>Sepiapterin reductase</term>
<term>Tetrahydrobiopterin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sepiapterin reductase</term>
<term>Réaction chaîne polymérase</term>
<term>Bioptérine(tétrahydro)</term>
<term>Parkinson maladie</term>
<term>Homme</term>
<term>Expression génique</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The PARK3 locus on chromosome 2pl3 has shown linkage to both the development and age of onset of Parkinson's disease (PD). One candidate gene at this locus is sepiapterin reductase (SPR). Sepiapterin reductase catalyzes the final step in the biosynthetic pathway of tetrahydrobiopterin (BH<sub>4</sub>
), an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. The expression of SPR was assayed using semiquantitative real-time RT-PCR in human post-mortem cerebellar tissue from neuropathologically confirmed PD cases and neurologically normal controls. The expression of other enzymes involved in BH<sub>4</sub>
 biosynthesis, including aldose reductase (AKR1B1), carbonyl reductase (CBR1 and CBR3), GTP-cyclohydrolase I (GCH1), and 6-pyruvoyltetrahydrobiopterin (PTS), was also examined. Single-nucleotide polymorphisms around the SPR gene that have been previously reported to show association to PD affection and onset age were genotyped in these samples. Expression of SPR showed a significant 4-fold increase in PD cases relative to controls, while the expression of AKR1B1 and PTS was significantly decreased in PD cases. No difference in expression was detected for CBR1, CBR3, and GCH1. Genetic variants did not show a significant effect on SPR expression, however, this is likely due to the low frequency of rare genotypes in the sample. While the association of SPR to PD is not strong enough to support that this is the PARK3 gene, this study further implicates a role for SPR in idiopathic PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Tobin, Jennifer E" sort="Tobin, Jennifer E" uniqKey="Tobin J" first="Jennifer E." last="Tobin">Jennifer E. Tobin</name>
</noRegion>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<name sortKey="Jing Cui" sort="Jing Cui" uniqKey="Jing Cui" last="Jing Cui">JING CUI</name>
<name sortKey="Karamohamed, Samer" sort="Karamohamed, Samer" uniqKey="Karamohamed S" first="Samer" last="Karamohamed">Samer Karamohamed</name>
<name sortKey="Laramie, Jason M" sort="Laramie, Jason M" uniqKey="Laramie J" first="Jason M." last="Laramie">Jason M. Laramie</name>
<name sortKey="Laramie, Jason M" sort="Laramie, Jason M" uniqKey="Laramie J" first="Jason M." last="Laramie">Jason M. Laramie</name>
<name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C." last="Latourelle">Jeanne C. Latourelle</name>
<name sortKey="Mckee, Ann C" sort="Mckee, Ann C" uniqKey="Mckee A" first="Ann C." last="Mckee">Ann C. Mckee</name>
<name sortKey="Mckee, Ann C" sort="Mckee, Ann C" uniqKey="Mckee A" first="Ann C." last="Mckee">Ann C. Mckee</name>
<name sortKey="Mckee, Ann C" sort="Mckee, Ann C" uniqKey="Mckee A" first="Ann C." last="Mckee">Ann C. Mckee</name>
<name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name>
<name sortKey="Tobin, Jennifer E" sort="Tobin, Jennifer E" uniqKey="Tobin J" first="Jennifer E." last="Tobin">Jennifer E. Tobin</name>
<name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B." last="Wilk">Jemma B. Wilk</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
</region>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue

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	La maladie de Parkinson au Canada (serveur d'exploration)
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